Pharmacology of Chloroquine: Potential Mechanism of Action against Coronavirus

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BEMS Reports,2020,6,1,9-10.
Published:May 2020
Type:Research Article
Author(s) affiliations:

Arun HS Kumar*

Veterinary Biosciences, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, IRELAND.


Background: Chloroquine and hydroxychloroquine are recently reported to be effective in treating SARS-CoV-2 illness. The pharmacological mechanisms of this clinical benefit are continued to be explored. Materials and Methods: Using molecular docking tools in this study the binding affinity of Chloroquine and hydroxychloroquine were tested against two key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) involved in viral attachment and 2) main protease (6Y84) involved in viral replication. Results: Chloroquine and hydroxychloroquine showed very effective binding affinity against both the SARS-CoV-2 targets. While the binding affinity against main protease was higher, multiple binding sites were observed on the surface glycoprotein of SARS-CoV-2. Conclusion: Chloroquine and hydroxychloroquinehave the potential to prevent SARS-CoV-2 attachment, entry and replication by directly binding to SARS-CoV-2 surface glycoprotein and its main protease.