Pathogenesis of Covid-19 – Pandemonium of the Pandemic in Pandora's Box

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BEMS Reports,2020,7,1,xx-xx.
Published:June 2020
Type:Review Article
Author(s) affiliations:

Aditi Venkat Goyal1, Samarth Shukla1, Sourya Acharya2, Sunita Vagha1, Venkat Goyal3

1Department of Pathology, JawaharlalNehru Medical College, DMIMSDU, Wardha

2Department of Medicine, JawaharlalNehru Medical College, DMIMSDU, Wardha

3Consultant Cardiologist, Riddhi Vinayak Multispeciality Hospital


The 2019 novel coronavirus disease (Covid-19 or SARS-CoV-2), first detected in December 2019 in Huanan Seafood Market, in Wuhan province of China, didn’t take more than a month to be declared as a pandemic by World Health Organization (WHO) and still remains to be a concern as a global public health threat. The inception of SARS-CoV-2 has been identified as the third introduction of a highly pathogenic coronavirus after Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome coronavirus (MERS-CoV) in merely two decades. In this review, we illustrate the general features of coronavirus and highlight the pathogenesis of the disease, bringing forth the different theories of disease progression which may help clinicians and other health professionals to achieve a direction for further research, therapeutic protocols and development of the vaccine for combating SARS-CoV-2 infection.