Background: Chlorhexidine (CHX) is considered as a gold standard of antimicrobial rinses. Various anti-calculus mouthrinse are available in the market However, little is known of its effectiveness. Aim: The aim of this study was to evaluate the clinical changes after the usage of anti-calculus mouthrinse and 0.12% CHX. Subjects and Methods: In a randomized clinical trial, 30 patients with dental plaque-induced gingivitis were assigned to two groups i.e. Experiment Group A (Anti-calculus mouthrinse) and Control Group B (0.12% Chlorhexidine mouthrinse). Gingival index, plaque index, calculus index and salivary concentration scores were recorded at baseline and six months along with the feedback questionnaire. Results: Intragroup comparison in both groups showed that all the clinical parameters scores were statistically significant after six months as compared to baseline. Intergroup comparison showed that Anti-calculus mouthrinse statistically showed more significant reduction in all the clinical parameters scores from base line to six months. Conclusion: Anti-calculus mouthrinse significantly reduced the clinical symptoms of plaque-induced gingivitis compared to 0.12% CHX with no adverse effects.