TY - JOUR AU - Kumar, Arun HS PY - 2020/05/21 Y2 - 2024/03/28 TI - Pharmacology of Chloroquine: Potential Mechanism of Action against Coronavirus JF - Biology, Engineering, Medicine and Science Reports JA - BEMS Reports VL - 6 IS - 1 SE - Original Research Article DO - 10.5530/bems.6.1.3 UR - https://bemsreports.org/index.php/bems/article/view/28 SP - 09-10 AB - <p style="text-align: justify;"><strong>Background:</strong> Chloroquine and hydroxychloroquine are recently reported to be effective in treating SARS-CoV-<sub>2 </sub>illness. The pharmacological mechanisms of this clinical benefit are continued to be explored. <strong>Materials and Methods</strong>: Using molecular docking tools in this study the binding affinity of Chloroquine and hydroxychloroquine were tested against two key SARS-CoV-<sub>2 </sub>targets i.e., 1) surface glycoprotein (6VSB) involved in viral attachment and 2) main protease (6Y84) involved in viral replication. <strong>Results:</strong> Chloroquine and hydroxychloroquine showed very effective binding affinity against both the SARS-CoV-<sub>2</sub> targets. While the binding affinity against main protease was higher, multiple binding sites were observed on the surface glycoprotein of SARS-CoV-<sub>2.</sub><strong> Conclusion</strong>: Chloroquine and hydroxychloroquinehave the potential to prevent SARS-CoV-<sub>2</sub> attachment, entry and replication by directly binding to SARS-CoV-<sub>2 </sub>surface glycoprotein and its main protease.</p> ER -